The respiratory depressant consequences of opioids contain carbon dioxide retention and secondary elevation of cerebrospinal fluid force, and could be markedly exaggerated within the existence of head injury, other intracranial lesions or possibly a pre-existing boost in intracranial stress.Individuals should be mindful that PERCOCET tablets includ

In the pharmacokinetic analyze of oxycodone in sufferers with stop-stage liver ailment, oxycodone plasma clearance diminished as well as the elimination half-lifetime enhanced. Treatment ought to be exercised when oxycodone is Utilized in people with hepatic impairment.In cases like this, abrupt discontinuation of the opioid may well bring about a